Document Details

Document Type : Article In Journal 
Document Title :
Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges
Inflammatory mediators in osteoarthritis: A critical review of the state-of-the-art, current prospects, and future challenges
 
Document Language : English 
Abstract : We appreciate the efforts of Anna Litwic and her colleagues [1] for writing a well-advised comment on our published review article entitled “Inflammatory mediators in osteoarthritis: A critical review of the state-of-the art, prospects, and future challenges” [2]. In their recent letter, Litwic et al. [1] have highlighted the noteworthy results of their previous research on the relationship between baseline inflammatory factors and rate of radiographic development of knee osteoarthritis (OA) over a period of 10 years in oldermen andwomen. In their original work, they have demonstrated that baseline inflammatory factors did not correlate with the rate of radiographic knee OA progression over 10 years. Although, at the time of writing our review article we did not cite some of the results in this concept [3,4], in our paper, we have clearly stated in “Section 5. Imaging techniques for diagnosis of inflammation in OA” that “many studies have reported a weak correlation between pain and radiographic findings, in which some patients with advanced radiographic findings have shown no pain symptom and some patients with pain demonstrated no radiographic signs of OA”. This indicates that although radiographic techniques might be useful for OA diagnosis in early stages, they are almost always unable to fully track the progression of OA. Since finding early changes in OA by conventional radiographic methods is usually difficult,modern imaging techniques such as MRI and US are being increasingly used for investigating early signs and symptoms. Here once againwe emphasize that our critical review is in accordance with the findings reported by Litwic et al. [1] and the other articles which have concluded the same results [5–9]. We thank the authors for their interest in our review article and for taking the time to highlight their own significant contributions to the field. 
ISSN : 8756-3282 
Journal Name : Bone 
Volume : 85 
Issue Number : 1 
Publishing Year : 1437 AH
2016 AD 
Article Type : Article 
Added Date : Wednesday, July 12, 2017 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
Maryam RahmatiRahmati, Maryam ResearcherDoctorate 
Ali MobasheriMobasheri, Ali ResearcherDoctorate 
Masoud MozafariMozafari, Masoud ResearcherDoctoratemozafari.masoud@gmail.com

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